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Dr. Luis Mendoza
Instituto de Investigaciones Biomédicas, UNAM
Ciudad Universitaria
D.F. 04510, MEXICO
Phone:+52 (55)56229210   
e-mail: lmendoza at biomedicas.unam.mx

Abridged CV:

ACADEMIC BACKGROUND

Ph.D. in Biomedical Sciences.
Graduated with Honors on February 23rd, 2000.
Instituto de Ecología, Universidad Nacional Autónoma de México.

Bachelor Degree in Basic Biomedical Research.
Graduated with Honors on June 2nd,1993.
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México.

RESEARCH EXPERIENCE

Group Leader of the CompBioLab.
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México.
From May 2006 to date.

Bioinformatics Associate Scientist at Serono International S.A.
Serono Pharmaceutical Research Institute. Scientific Computing Group.
From February 2002, to March 2006.

Postdoctoral researcher at the Karolinska Institute.
Centre for Genomics and Bioinformatics. Group of Dr. Wyeth W. Wasserman.
From April 2000, to January 2002.

Ph.D. student at the Universidad Nacional Autónoma de México
Instituto de Ecología. Group of Dr. Elena Alvarez-Buylla.
From August 1995, to February 2000.

Graduate student at the Universidad Nacional Autónoma de México.
Instituto de Química. Group of Dr. Jaime Lagúez-Otero.
From January 1994, to July 1995.

Undergraduate student at the Universidad Nacional Autónoma de México.
Instituto de Investigaciones Biomédicas, Group of Dr. Gonzalo Martínez de la Escalera.
From October 1990, to December 1993.

HONORS

Thomson Reuters Award, 2009 (México)

RESEARCH PUBLICATIONS

Alfredo Rodríguez, Leda Torres, Ulises Juárez, David Sosa, Eugenio Azpeitia, Benilde García-de Teresa, Edith Cortés, Rocío Ortíz, Ana M. Salazar, Patricia Ostrosky-Wegman, Luis Mendoza, and Sara Frías (2015).
Fanconi Anemia Cells with Unrepaired DNA Damage Activate Components of the Checkpoint Recovery Process.
Theoretical Biology and Medical Modelling In press

Jennifer Enciso, Luis Mendoza, and Rosana Pelayo (2015).
Normal vs Malignant Hematopoiesis: the Complexity of Acute Leukemia Through Systems Biology.
Frontiers in Genetics 6: 290.

Mariana Martinez-Sanchez, Luis Mendoza, Carlos Villarreal, and Elena R. Alvarez-Buylla (2015).
A Minimal Regulatory Network of Extrinsic and Intrinsic Factors Recovers Observed Patterns of CD4+ T Lymphocyte Differentiation and Plasticity.
PLoS Computational Biology 11(6): e1004324.
PubMed 

Mariana Díaz-Zaragoza, Ricardo Hernández-Ávila, Tzipe Govezensky, Luis Mendoza, Dulce María Meneses-Ruíz, and Pedro Ostoa-Saloma (2015).
Comparison patterns of 4 T1 antigens recognized by humoral immune response mediated by IgG and IgM antibodies in female and male mice with breast cancer using 2D-immnunoblots.
Immunobiology. 220: 1050-1058.
PubMed 

Nathan Weinstein, Elizabeth Ortiz-Gutierrez, Stalin Muñoz, David A. Rosenblueth, Elena R. Alvarez-Buylla and Luis Mendoza (2015).
A model of the regulatory network involved in the control of the cell cycle and cell differentiation in the Caenorhabditis elegans vulva.
BMC Bioinformatics 16: 81.
PubMed  Full text 

Pablo Martínez-Sosa and Luis Mendoza (2013).
The regulatory network that controls the differentiation of T lymphocytes.
BioSystems 113: 96-103.
PubMed  Full text  

Luis Mendoza (2013).
A virtual culture of CD4+ T lymphocytes.
Bulletin of Mathematical Biology 75: 1012-1029.
PubMed  Full text 

Nathan Weinstein and Luis Mendoza (2013).
A network model for the specification of vulval precursor cells and cell fusion control in Caenorhabditis elegans.
Frontiers in Genetics 4: 112.
PubMed  Full text 

Eugenio Azpeitia, Nathan Weinstein, Mariana Benítez, Luis Mendoza, and Elena R. Alvarez-Buylla (2013).
Finding missing interactions of the Arabidopsis thaliana root stem cell niche gene regulatory network.
Frontiers in Plant Science 4: 110.
PubMed  Full text 

Nathan Weinstein and Luis Mendoza (2012).
Building qualitative models of plant regulatory networks with SQUAD.
Frontiers in Plant Science 3: 72.
PubMed  Full text 

Alfredo Rodríguez, David Sosa, Leda Torres, Bertha Molina, Sara Frías, and Luis Mendoza (2012).
A Boolean network model of the FA/BRCA pathway.
Bioinformatics 28: 858-866.
PubMed  Full text 

María Fernanda Higareda, Otto Geiger, Luis Mendoza, and Rafael A. Méndez-Sánchez (2012).
Evidence of codon usage in the nearest neighbor spacing distribution of bases in bacterial genomes.
Physica A 391: 1255-1269.
DOI  Full text 

Luis Mendoza and Fátima Pardo (2010).
A robust model to describe the differentiation of T-helper cells.
Theory in Biosciences 129: 283-293.
PubMed  Full text  
Supplementary files: 1 2 3 

Yara-Elena Sánchez-Corrales, Elena R. Álvarez-Buylla, and Luis Mendoza (2010).
The Arabidopsis thaliana flower organ specification gene regulatory network determines a robust differentiation process.
Journal of Theoretical Biology 264: 971-983.
PubMed   Full text 
Correction: Table 1 

Abhishek Garg, Alessandro Di Cara, Ioannis Xenarios, Luis Mendoza, and Giovanni De Micheli (2008).
Synchronous vs. asynchronous modelling of gene regulatory networks.
Bioinformatics 24: 1917-1925.
PubMed   Full text 

Alessandro Di Cara, Abhishek Garg, Giovanni De Micheli, Ioannis Xenarios and Luis Mendoza (2007).
Dynamic simulation of regulatory networks using SQUAD.
BMC Bioinformatics 8: 462.
PubMed  Full text 

Abhishek Garg, Luis Mendoza, Ioannis Xenarios, and Giovanni De Micheli (2007).
Modeling of Multiple Valued Gene Regulatory Networks.
Conf. Proc. IEEE Eng. Med. Biol. Soc. 2007 1: 1398-1404.
PubMed  Full text 

Abhishek Garg, Ioannis Xenarios, Luis Mendoza, and Giovanni DeMicheli (2007).
An efficient method for dynamic analysis of gene regulatory networks and in silico gene perturbation experiments.
RECOMB 2007, Lecture Notes in Computer Science 4453: 62-76.
DOI  Full text 

Luis Mendoza (2006).
A network model for the control of the differentiation process in Th cells.
BioSystems 84: 101-114
PubMed  Full text 

Luis Mendoza and Ioannis Xenarios (2006).
A method for the generation of standardized qualitative dynamical systems of regulatory networks.
Theoretical Biology and Medical Modelling 3:13
PubMed  Full text 

Elisabeth Remy, Paul Ruet, Luis Mendoza, Denis Thieffry and Claudine Chaouiya (2006).
From logical regulatory graphs to standard petri nets: Dynamical roles and functionality of feedback circuits.
Transactions on Computational Systems Biology VII, Lecture Notes in Computer Science 4230: 56-72
Full text  DOI 

Boris Lenhard, Albin Sandelin, Luis Mendoza, Pär Engström, Niclas Jareborg, and Wyeth W. Wasserman (2003).
Identification of conserved regulatory elements by comparative genome analysis.
Journal of Biology 2:13
PubMed  Full text 

Luis Mendoza and Elena R. Alvarez-Buylla (2000).
Genetic regulation of root hair development in Arabidopsis thaliana: a network model.
Journal of Theoretical Biology 204:311
PubMed  Full text 

Luis Mendoza, Denis Thieffry and Elena R. Alvarez-Buylla (1999).
Genetic control of flower morphogenesis in Arabidopsis thaliana: a logical analysis.
Bioinformatics 15:593
PubMed  Full text 

Luis Mendoza and Elena R. Alvarez-Buylla (1998).
Dynamics of the genetic regulatory network for flowering in Arabidopsis thaliana.
Journal of Theoretical Biology 193: 307-319.
PubMed  Full text 

Luis Mendoza, Mariana Mondragón and Jaime Lagúnez-Otero (1998).
Interactions of the 530 ribosomal site with subregions of mRNA.
Biosystems 46:293
PubMed  Full text 

Luis Mendoza and Jaime Lagúnez-Otero (1996).
The ribosome as an exon detector.
Biosystems 38:45
PubMed  Full text 

BOOKS AND CHAPTERS

Enrique Mendoza Sierra, Luis Antonio Mendoza Sierra, Margarita Dalila Mendoza Gálvez, Iliana Ahtenea Mendoza Gálvez, Enrique Mendoza Gálvez y Margarita Gálvez Barón (2015).
La biblia del médico general: Diagnóstico y tratamiento de las cien enfermedades más frecuentes.
Amazon Digital Services, Inc. ASIN: B00UMIS2S2.
Amazon

Luis Antonio Mendoza Sierra y Enrique Mendoza Sierra (2014).
Biología II.
1a Reimpresión. Trillas, 2009. ISBN: 978-607-17-0078-0.
info Publisher

Luis Mendoza (2014).
Encyclopedia entries for: Qualitative differential equations, Piecewise-linear models, and Standardized Qualitative Dynamical Systems.
In: Concise Encyclopaedia of Bioinformatics and Computational Biology, 2nd Edition. John M. Hancock and Marketa J. Zvelebil (Editors).
Wiley-Blackwell. ISBN: 978-0-470-97871-9.

Pascal Kahlem, Alessandro DiCara, Maxime Durot, John M. Hancock, Edda Klipp, Vincent Schächter, Eran Segal, Ioannis Xenarios, Ewan Birney, and Luis Mendoza (2011).
Strengths and Weaknesses of Selected Modeling Methods used in Systems Biology.
In: Systems and Computational Biology - Bioinformatics and Computational Modeling. Dr. Ning-Sun Yang (Ed.). InTech. 978-953-307-875-5.
Full text

Luis Antonio Mendoza Sierra y Enrique Mendoza Sierra (2011).
Biología I.
1a Edición. Trillas, 2011. ISBN: 978-607-17-0640-9.
info Publisher

Luis Antonio Mendoza Sierra y Enrique Mendoza Sierra (2009).
Biología II.
1a Edición. Trillas, 2009. ISBN: 978-607-17-0078-0.
info Publisher

Elizabeth Santiago-Cortés and Luis Mendoza (2008).
Chapter XXXI: Discrete State Networks as a Suitable Approach for the Analysis of Genetic Regulation.
In: Handbook of Research on Systems Biology Applications in Medicine. Andriani Daskalaki (Ed.). Medical Information Science Reference.
Publisher

Francisco Vergara-Silva, Caroline Burgeff d`Hondt, Liz Yazmín Izquierdo, Alicia Gamboa de Buen, Rosalinda Tapia-López, Luis Mendoza,and María Elena Alvarez-Buylla Roces (2003).
Genes homeóticos y mecanismos moleculares de diferenciación.
In: Biología Celular y Molecular. Luis Felipe Jiménez and Horacio Merchant (Eds). Prentice Hall, México.
Publisher

Gonzalo Martínez de la Escalera, Luis Mendoza, Alejandra Ochoa and Dirk Hol (1993).
Nuevas tendencias en el análisis experimental de la comunicación neuroendócrina: las células GT1.
In: Comunicación neuroendócrina: bases celulares y moleculares.
Clapp y Martínez de la Escalera (Eds.). SMCF, CONACYT, SEP. México.

OTHER PUBLICATIONS

Luis Mendoza (2009).
Modelado de multitudes.
Gaceta Biomédicas 14(1): 10-11.
Full text

Fátima Pardo y Luis Mendoza (2008).
Los sistemas dinámicos discretos.
Gaceta Biomédicas 13(2): 12-14.
Full text

Luis Mendoza (2007).
Modelado de linfocitos T cooperadores.
Gaceta Biomédicas 12(3): 6.
Full text

Luis Mendoza (2006).
A network model for the differentiation of T-helper lymphocytes.
Foro-Red-Mat 13: 3.
Full text

Luis Mendoza, Francisco Caviedes and Nydia Lara (1998)
The metaphysics behind studies of neural motor control.
In: Research-in-progress, Volume V. George E. Lasker (Ed.). The International Institute for Advanced Studies in Systems Research and Cybernetics. 1998. p41-45.
Full text

Elena Alvarez-Buylla, Luis Mendoza and Francisco Vergara (1996).
Orden y caos en la biología: la autoorganización como fuente de complejidad en los seres vivos.
Universidad de México 540:58
Full text